The Role of Proteolytic Enzymes Mopar in SARS-CoV Replication SARS-CoV replication requires the proteolytic processing of the replicase polyprotein. This process requires papain-like and chymotrypsin-like proteases, making them important antiviral drug development targets. This article will highlight the SARS-CoV PLpro, which is unique among proteases. It has a zinc-binding motif, a free active site, and …
Proteolytic Enzymes Covid | Mechanism of substrate recognition Read More »
Types of Reversible Enzyme Inhibition There are two major types of enzyme inhibition – irreversible and reversible. When the inhibitor binds covalently to the enzyme, it prevents its activity. The dissociation of the inhibitor-enzyme complex is slow, but it does happen. Reversible inhibition can be reverted, while irreversible inhibition is permanent. Read on to learn …
Reversible Enzyme Inhibition | Competitive inhibition Read More »
Causes of Elevated Liver Enzymes A patient with elevated liver enzymes may have a variety of conditions. For example, Stauffer’s syndrome, Succinate dehydrogenase complex, or polyclonal gammopathy on serum protein electrophoresis can cause elevated liver enzymes. If you have non-hepatic causes for elevated liver enzymes, read on to learn about those conditions. It can help …
Renal Cell Carcinoma Elevated Liver Enzymes | Stauffer’s syndrome Read More »
Proton Tunnelling in Enzymes The mechanism of proton tunneling in enzymes has long been debated. The prevailing view is that the process requires thermal activation of the substrate. In contrast, the VEGST theory does not require such activation. It explains the temperature dependence of H-transfer by thermally induced breathing of the enzyme molecules. In contrast, …
Proton Tunneling Enzyme | A unique microenvironment Read More »
The Mechanisms of the Porcupine Enzyme The inhibition of the porcupine enzyme in tumors correlates with the development of immune tolerance within the tumor microenvironment (TME). Interacting with porcupine pathways in cancer cells may facilitate improved immune responses, thereby preventing resistance to checkpoint inhibitors and overcoming existing tolerance. But how do we target porcupine enzymes? …
Zero Order of Reaction Enzyme Kinetics This article will learn about the Zero-order of reaction enzyme kinetics and the Michaelis-Menten model. In addition, you’ll learn about the Rate-determining step and the Specificity constant. This article should answer some of the most common questions about reaction enzyme kinetics. Then, you’ll be able to use this information …
Order of Reaction Enzyme Kinetics | Zero-order reactions Read More »
How Noncompetitive Inhibition of Enzymes Occurs Noncompetitive inhibition of enzymes occurs in several different ways. It can be reversible or involves direct binding to the enzyme’s active site. Unlike competitive inhibition, the binding of an inhibitor does not prevent the enzyme from binding a substrate, but it can block the formation of the product for …
Noncompetitive Inhibition of Enzymes Occurs | Irreversible inhibition Read More »
Nagalase Enzyme You’ve arrived in the right place if you are interested in finding out more about the a-N-acetylgalactosaminidase enzyme. This article will give you the inside scoop on this important enzyme. This enzyme is also known to cause HIV, influenza, and cancer, among other things. It may also play a role in autoimmune responses. …
The Role of Nagalase in Cancer Treatment The nagalase enzyme is responsible for cleaving off immune activator binding sites on vitamin D. These proteins activate macrophages in infectious diseases, including cancer, and immune system function. Cancer cells and virus particles produce the enzyme, which targets the GcMAF protein facilities. It can wipe out T lymphocytes …
Nagalase Enzyme Vitamin D | Clinical significance of nagalase Read More »
The Monomer of Enzymes What are the different types of molecules that are the monomer of enzymes? These molecules are composed of carbon, amino acids, polypeptides, cellulose, and various substances. Each one has a carboxyl or amine group. Let’s look at each type. Here are some examples. Glucose is one of these molecules. It is …
Monomer of Enzymes | 20 major types of amino acids Read More »
MMP-13 Enzyme and Neuropathy In this article, we’ll examine the part of the MMP-13 enzyme in neuropathic pain and how it may be able to treat diabetic neuropathy. We will also touch on the role of annexin A2, TLR4, and lysozyme. We’ll also discuss how the MMP-13 enzyme can regulate the immune system. But first, …
Mmp 13 Enzyme and Neuropathy | Mitochondrial filamentation Read More »
Understanding the Kinetics of Enzyme Catalysis Enzymes are vital for breaking down dietary proteins into smaller components called peptides. Enzymes such as chymotrypsin and kymotrypsin are responsible for this process. Both are capable of cleaving peptide bonds at specific locations on the backbone. These two enzymes cleave adjacent to aromatic amino acids. Understanding the cleavage …
Kinetics of Enzyme Catalysis PPT | The kinetics of enzyme catalysis Read More »
Isomerase Enzyme The isomerase enzyme is responsible for regulating the redox state of the cell membrane by reversibly converting the ion-sensitive monophosphate group into the divalent cation. Several factors control the activity of the enzyme. These factors include the Hydrophobic binding surface, the Dependence on Divalent Cations, and Mutations. Let us explore the different aspects …
Is Water an Enzyme Catalyst? The structure of a protein is a great resource for understanding how the enzyme works. These features include Structure, Dynamics, Catalytic efficiency, and Selectivity. The following sections describe these properties in greater detail. We will also discuss how water binds to enzymes. Once you understand these aspects, you can apply …
Is Water an Enzyme | Simulations of water enzymes Read More »
What is Dehydrogenase an Enzyme? What is dehydrogenase? Humans name enzymes, and most of the time, the names are descriptive of their function. Dehydrogenase, for instance, is named for the reverse reaction it undergoes: it removes hydrogen from one thing and transfers it to another. That’s a pretty cool feature. We will discuss FAD, Pyruvate …
Is Dehydrogenase an Enzyme | Lactate dehydrogenase Read More »
Detection of HSV-2 by a Liver Enzyme Test Detection of HSV-2 by a liver enzyme test is possible, but what are the sensitivity and specificity limits? This article will discuss the issues associated with this test, including its sensitivity and specificity in immune-competent patients. The article also discusses the role of serum and urine HSV-2 …
How Do Enzymes Colocalize Substrates? We will discuss the means of covalent and acid-base catalysis, the substrate-channeling mechanism, and the Molecular interactions of enzymes. In addition, we will look at the role of covalent bonds in catalysis. Hopefully, by the end of the article, you’ll better understand the role of covalent bonds in enzyme catalysis. …
How do Enzymes Colocalize Substrates | Covalent catalysis Read More »
Herpes and Liver Enzymes A recent study examined the association between herpes and liver enzymes. While this correlation did not hold for every patient, it was statistically significant. A study of nine individuals diagnosed with herpes-hepatitis found that herpes on liver enzymes correlated with the presence of hepatic lesions. For instance, liver enzymes elevated on …
Herpes and liver Enzymes | Acute herpes infection Read More »
The Role of Enzymes in Photosynthesis Plants use an array of enzymes to convert sunlight into usable energy, and Rubisco is one of the most important. It makes up about half of the protein in chloroplasts and consists of eight identical large subunits. Both large and small subunits are encoded by mRNA, transcribed from chloroplast …
Enzymes in Photosynthesis | One of four GAPC-type GAPDHs Read More »
Examples of Which Macromolecules Are Involved? A macromolecule is any substance that can perform a specific function, such as converting one form of energy to another. Some examples of these types of molecules are enzymes, which are polypeptides. They act as catalysts, catalyzing biochemical reactions such as dehydration and membrane fusion. Enzymes can also denature, …